Notification according to Chapter 2, Section 10 of the Finnish Securities Market Act relating to decrease in holdings

BIOTIE THERAPIES CORP. STOCK EXCHANGE RELEASE December 18, 2009, at 1 p.m. Notification according to Chapter 2, Section 10 of the Finnish Securities Market Act relating to decrease in holdings Biotie Therapies Corp. (?Company?) has gained knowledge of the notifications regarding the following changes in holdings in accordance with Chapter 2, Section 9 of the Finnish Securities Markets Act. The change (decrease below 1/10 of total number of shares) in holdings relate to the increase in the total number of shares in the Company as a result of the directed share offering registered on 14 December 2009. Pequot Healthcare Fund, L.P., Pequot Healthcare Offshore Fund, Inc., Pequot Diversified Master Fund, Ltd., Pequot Healthcare Institutional Fund, L.P. and Pequot Healthcare Emerging Markets Master Fund, Ltd. (jointly ?Pequot?) have notified that as a result of the Company issuing 14,432,000 new shares in the directed offering, the joint holdings of Pequot has decreased below 1/10 to 9.63% of total number of shares and votes in the Company. The holdings in accordance with Chapter 2, Section 9 of the Finnish Securities Markets Act of which the Company has gained knowledge is described below. Name of the shareholder Shares % of shares after the issuance   of new shares Pequot Healthcare Fund, L.P. 5,756,935 3.63% Pequot Healthcare Offshore Fund, 4,527,283 2.85% Inc. Pequot Diversified Master Fund, Ltd. 922,300 0.58% Pequot Healthcare Institutional 1,582,506 1.00% Fund, L.P. Healthcare Emerging 2,506,470 1.58% Markets Fund, Ltd. PEQUOT TOTAL 15,295,494 9.63% The registered number of shares in Biotie Therapies Corp. is 158,752,560 and the number of voting rights attached to the shares amounts to 158,289,305. In Turku, 18 December 2009 Biotie Therapies Corp. Timo Veromaa, President and CEO For further information, please contact: Virve Nurmi, Biotie Therapies Corp. tel. +358 2 274 8900, e-mail: virve.nurmi@biotie.com www.biotie.com DISTRIBUTION: NASDAQ OMX Helsinki Ltd Main Media DISTRIBUTION NASDAQ OMX Helsinki Ltd Main Media [HUG#1364807]