Disclosure of shareholdings

Pursuant to article 20 BEHG Deutsche Bank AG, Taunusanlage 12, 60325 Frankfurt, Germany has announced on August 22, 2007 to BB BIOTECH AG, Vordergasse 3, 8200 Schaffhausen, Switzerland that its holding in voting rights of BB BIOTECH AG as per August 16, 2007 accounted to 5.59% (1 257 796 voting rights). As participation at August 16, 2007 comprises the following positions: 872 145 bearer shares (872 145 voting rights, 3.88%), 1 200 000 long call warrants (211 112 voting rights, 0.94%) and 2 630 505 short put options (174 539 voting rights, 0.78%). To convert these put options into shares is not possible. For further information please contact: Bellevue Asset Management AG, Seestrasse 16, 8700 Küsnacht, Switzerland Dr. Christian Lach or Anja Stubenrauch, Tel. +41 44 267 67 00 --- End of Message --- BB BIOTECH AG Vordergasse 3 Schaffhausen Switzerland WKN: 888509; ISIN: CH0001441580; Index: SBIOM, IGSP, SLIFE; Listed: Investment Companies in SWX Swiss Exchange;